is it safe or not to use it? We need more people like you. The full indication is: "For dogs with, or at risk from, mixed external and internal parasitic infestations. Ive talked to Collie and Aussie owners who absolutely swear by their Seresto collars and others who are livid because they made their dogs neck bald! Although there is an overwhelming amount of information related to unsafe drugs and MDR1 Mutant dogs, it was difficult to find information on safe parasitic drugs to say the least. According to a thorough study conducted on MDR1-affected dogs, Interceptor and its more affordable generic, MilbeGuard, rank high in ML safety due to their use of the compound called milbemycin oxime. Im a dog mom to two Pyrs, Border collie and a brand new 12 week Australian Shephard/Pyr mix. But frankly we're baffled that they've approved it. for dogs 1.3-2.5 kg 5 for dogs >2.5-5 kg 10 for dogs >5-10 kg 20 . Will you be updating this article with regard to Seresto? I think this is a couple years old. These generics include Tri-Heart Plus, Iverhart Plus, and Nuheart. One observation: You mention that Credelio has fewer reported seizures (6 in as many months) than other drugs in the isoxazaline class. But the drug works just like Bravecto and Nexgard it destroys flea and tick nervous systems. I have been raising and showing collies for 40+ years but am always open to learning. And safe travels to you and Lola in the future. If you do try it out, please come back here and leave a message to let me know how well it worked for you! The best thing about Seresto is how long it can do its job up to 8 months! The parasite protections that target multiple parasites with just one topical application or administration of a pill are extremely appealing due to their convenience. However, it is strong and can cause a skin reaction. Give Hollie Collie a good butt scratch or ear rub from me. Since Collies and cats go together so well, I have to include this caution for cats: Some ingredients used to kill ticks, such as permethrin (used in K9 Advantix and other products) and amitraz (used in Certifect and the Preventic collar), are toxic to cats, which can be a problem in a household that includes both, especially if they are friendly with each other. If you have cats that share sleeping space with and/or like to groom your dogs, Advantix is probably not the best product for you. (I have to give them baths with a very mild or medicated shampoo.) I did not need to try the Seresto collar. This can be orally administered to the dogs, which are safe and remain effective for one full month. Thank you again for all your help : ). ? Appreciated!!! While my pain levels went down, I noticed that my heart rate went up! Nothing could be done for them. Unfortunately, both my Collies and to a lesser extent my Aussie mix have some skin sensitivities: so K9 Advantix II and Seresto, while very effective, would most likely cause them skin irritation. Could you send the link to that article you found? Channel 2 Consumer Investigator Jim Strickland has obtained records showing dog owners believe the . My border collie started having seizures (he was on Bravecto AND Sentinel) and the vet never said anything about the gene mutation. ), The lack of accessible information on the topic of safe parasite protection left me so frustrated that I decided to write my own article. 2022 Collie Chatter. Hes just a puppy himself and was already started on Interceptor and Credelio. A mutation of this gene causes sensitivity to Ivermectin and a number of other drugs. Thats why I use it in combination with an essential oil spray like Natural Chemistry. She was obviously in discomfort. I actually just updated the section on Seresto collars today with new info and a link to a USA Today article about side effects resulting in seizures and even death. I just took her off Sentinel Flavor Tabs. The manufacturer of ProHeart has tested the product for safety in dogs with the MDR1 mutation. Are you referring to Advantage Multi, Advantage II, or a different product I didnt cover in the article? Simparica 5 mg chewable tablets for dogs 1.3-2.5 kg Simparica 10 mg chewable tablets for dogs >2.5-5 kg Simparica 20 mg chewable tablets for dogs >5-10 kg . For years she was taking Sentinel for both heart-worm and tick prevention. Its in lots of grain-based foods because lots of grains are stored with diatomaceous earth to keep the bugs from eating the grain.. Whether a dog reacts depends on the dosage of the drug. Your thoughts? (Im guessing based on your question about Prinovox that youre not in the US, so in case Frontline goes by a different name where you are just look for the active ingredients Fipronil and S-methoprene. ? Simparica TRIO (6.0 mg/0.12 mg/25. It comes in pill form, starts working within 30 minutes, and will kill all the fleas on a dog within 4 hours. For Guss veterinarian, Credelio is now the only member of the isoxazoline class that he will sell. March 1, 2022 Learn what medications may be dangerous for your dog with the MDRI genetic mutation. Ill list all the options I looked into (including several Ive personally tried), along with whether theyre considered safe to use, use with caution, or a complete no-no. The topical medicines seem to work best with her, but dont do much to keep the tics at bay. Also, it is not recommended for use with other medications. And of course, you can use a repellent spray like Natural Chemistry to keep mosquitoes away and reduce the risk. Does your veterinarian give other reasons for prescribing Credelio vs. similar brands? From the standpoint of MDR1 dogs, it is safe. Parastar Plus is not something Ive personally used, but it should be safe as one of its active ingredients is Fipronil (which is in Frontline) and the other active ingredient, Cyphenothrin, is in the same family of drugs as Permethrin. However, the safety of Interceptor Plus has not been evaluated for pregnant or lactating dogs, and it is not recommended for cats. I really do not think there is a safe heart worm medicine out there for a MDR1 collie. Our are both indoors and outdoors. I have been told that Advocate is safe for him at the recommended dose. I can live with that. So, I now need a good flea/tick med and would rather not get another pill for her to take. Please help! (One such knockoff, Pet Armor Plus, is even available at Walmart.). Since switching to Bravecto about 1.5 yr ago, zero ticks on either dog! Thank you for writing this article. I disagree. I cant speak from personal experience on this, but the Seresto effectiveness/safety question has come up in an international Rough Collies group Im part of on Facebook. I have a cat myself, so I appreciate the information. Unlike many other external parasite treatments that only kill little bloodsuckers after theyve bitten the dog, K9 Advantix claims to kill them on contact. Ive had success using Burts Bees ear rinse on my dogs. Any suggestions? The manufacturer of Heartgard has tested the product for safety in dogs with the MDR1 mutation. At doses used to treat diarrhea, this drug will cause neurological toxicity in dogs with the MDR1 mutation. Low or high blood sugar. Unless youre, say, an expat living in China, you can definitely find a better option. I have a female 3 year old collie. Quick Navigation Thank you for the reminder! Remember she is fixed. (Basically, I did the boring work to bring you the helpful information.). . Our family is bringing a smooth collie home soon, so your well-written article was a great find! That indicates it is a strong chemical compound, so do watch for skin irritation. Thanks for reply. THREE OF THE 8 FEMALES WENT INTO ESTRUS. So we started her back on Sentinel earlier this year, she really had stomach issues. I got an email from the rescue agency that fussed that I hadnt given them their heartgard for this month. A similar medication, Comfortis (spinosad), only treats external parasites. I hate to use anything, but also tired of keeping my dogs in a bubble. The key to getting this spray to work well is to apply it well (rub against the lay of the coat while spraying the roots of the hair to get down to the skin); thoroughly (to the underbelly, legs, and paws); and often (at least once a week, more if your dog gets wet). Ive already modified this article a few times since I originally published it, and Im definitely keeping my eye on Credelio to see what else will come out about clinical trials or reported side effects. (I did try to use it to deworm my cat without great success, but that could just be because I couldnt get him to ingest a complete dose at once.) He said he himself uses Seresto collars on his Australian Shepherds, but that in his experience the collars tend to last 6 months for his fluffballs, not 8. The Wondercide website says, We recommend testing any new product you introduce to your pet or environment eight hours prior to a full application to ensure there are no sensitivities. With cedar oil being the main ingredient, it should be relatively safe; but its best to be cautious, especially as your girl has proven to be so sensitive. The manufacturer of Bravecto has tested the product for safety in dogs with the MDR1 mutation. I used Interceptor last year with no issues. Do you know what the ingredients are in the medicated shampoo? If you found this post helpful, you can leave me $1 or more tip on vocal.media or purchase one of our recommended dog products from Amazonso we can buy more dog supplies ourselves! No adverse effects were observed. Basically, the idea is that heartworms take a few months to develop anyway, so every few months you get your dog tested instead of merely annually and ONLY treat for heartworms if bloodwork reveals that your dog has contracted heartworms. Plus, Simparica's protection lasts for five weeks (35 days), and it does not decrease at the end of the month. However, it did make my Collies too itchy. One thing about Credelio is that it only breaks the flea life cycle at one point (kills adult fleas only after they bite the dog), so you may want to use a natural flea & tick repellent spray to increase its effectiveness. Any thoughts? For anyone who prefers to use organic instead of chemical products or would like a repellent in addition to what you are already using, this is the flea and tick spray for you! As the agency explained: Although FDA scientists carefully evaluate an animal drug prior to approval, there is the potential for new information to emerge after marketing, when the product is used in a much larger population. (New drugs continue to be highly monitored for the first three years following their release.). It seems unlikely for that much time to elapse before a reaction, but I would definitely consult with a veterinarian. Their treatment for this was nexgard and medicated baths. They were extremely helpful people. On September 20, 2018, the U.S. Food and Drug Administration (FDA) warned animal caregivers and veterinarians about the risk of serious neurologic events, including seizures, muscle tremors and ataxia, in dogs and cats treated with certain flea and tick medications. If you have a dog you suspect has Giardia, it really is best to see a veterinarian. I doubt it as he was on leash and Im always watching him. (Most vets are going to recommend to you the products they carry in stock, but you can order online from Chewy or pet pharmacies.) Be prepared to answer questions about whether your dog had a previous history with seizures, has any drug sensitivities, if anything else could possibly have triggered a seizure, and if she has had any seizures since the collar was removed. All I can tell you is that Ive personally used it for years with no adverse reactions, everyone in my local AKC Collie club has also used it without trouble, and Im not aware of negative reports that have reached the news. Is Simparica Trio safe for dogs with MDR1? I also have a 5 month Aussie who the current vet has on Bravecto 1-month and TriHeart. If you choose to use Advantage Multi, great care should be taken to only apply the liquid between your dogs neck and shoulder blades, where it cannot be reached by licking. Negative reactions such as vomiting, diarrhea, and tremors were only observed at supratherapeutic (higher than recommended) doses. WSU is the leader in identifying drugs that may be dangerous for dogs with the MDR1 mutation and can identify alternative medications and doses. Happy to help! The bottom line is, its best to avoid giving your Collie Heartgard or a similar medication. Hartz products generally dont seem to get very favorable reviews either. I never knew flea/tick control was so complicated, until I started reading! Before I got them home, they went into comas. Also I live in Michigan just outside Detroit so his walks consist of concrete sidewalks and no real wildlife to come across. I tried to review a variety of the most well-known parasite protection products out there, but if I left out any you are curious about, leave a comment below! I follow this advice, since Im a safe-is-better-than-sorry person. Either way, I certainly dont want to risk it for him again. Please log in again. I was leaning towards, but have not tried, the combination of Interceptor tablets (heartworm) + Credilio (flea and tick) tablets. I had success giving Credelio (active ingredient lotilaner instead of Simparicas sarolaner), but in all honesty I administered that based on my vets recommendation BEFORE I realized the FDA warning also applied to Credelio. ivermectin, selamectin)? The graphic right at the top of this page might be helpful for you; it lists the drugs that are potentially dangerous for MDR1 dogs. Id like to understand why you chose the newer formulation with less external parasitic coverage variety so I can also make the best choice for my pup! Water-fast after 48 hours. Pills or chews that protect dogs and cats against fleas can cause neurological problems such as stumbling or seizures, and pet owners need more warning, the Food and Drug Administration said Thursday. A1443) is a novel systemic ectoparasiticide and belongs to the class of isoxazolines, also including afoxolaner, lotilaner and sarolaner [ 1, 2 ]. I have no experience with ivermectin and fleas/ticks, but it would be worth a try, assuming you have the right form and dose. In light of this, Im categorizing all three of these oral flea/tick protection chews as use with caution, although in fairness I must note that a link between the occurrences and seizure-prone or MDR1 dogs has not been identified. Because I am only one person, the medication is relatively new, and it has active ingredients that are the same as more well-known medications that have been known to cause issues for many dogs, I didnt feel that I could give it an entirely glowing recommendation. What can I give my dog instead of Simparica Trio? Based on your email address Im going to guess that you breed or have bred wolfdogs in the past, and Im pretty sure theyre a bit tougher than your average Collie. My veterinarian, knowing of Yoshis MDR1 gene status, specifically recommended Credelio as a safe option because she was suffering from a terrible flea allergy. I am going to try WonderCide as recommended by my Vet for fleas. Children should be kept away from the dog for 2 hours until the liquid has had time to dry, and be sure to wash your hands after application. If you can, its always a good idea to consult with a vet who is knowledgeable about MDR1 and Collies. Kudos to you for going out of your way to manage your Collies health, and good luck as you continue to search for what will work best for her! Thank you for bringing this to my attention! Though water resistant, frequent bathing or swimming (once a month or more) will reduce the collars effective time to 5 months or less. Im leaning toward Frontline Plus based on what you wrote. (Your vet or a pet store associate may recommend otherwise, but bear in mind that they also want to make money.). The FDA approved Nexgard for flea treatment in dogs in September 2013, Bravecto in May 2014, Simparica in February 2016, and Credelio in January 2018. Thank you! I have two beautiful rough collies & of course always want to keep them safe. Share the results with your veterinarian to let them know to avoid or adjust the dose of certain medications. Ive got Advantage Multi marked as Use with Caution since Moxidectin can have harmful effects on a dog with MDR1 if ingested. The effectiveness of ProHeart 12 has not been evaluated in dogs less than 12 months of age. Since I live in Florida, Revolution is not the best choice for me as it only targets the dog tick. Specifically, does it contain any form of -mectin (i.e. No adverse effects were observed. Use with caution in dogs with a history of seizures. Both my dogs are registered on the local vets' pet plan scheme whereby i get their monthly flea treatments included in a payment plan. In hot, flea-infested areas like where I live in Florida, Parastar Plus might not be the best option; but its definitely something I would have tried when I still lived in Michigan. It was both well written, and concise. Have you reported the seizure to Bayer (the company that makes Seresto collars) and to the EPA? Fluralaner (syn. I know Simparica is more convenient since it means giving one monthly preventive instead of two, but the trade-off with the combo meds is that theyre usually stronger. At low doses, such as those used in heartworm prevention, ivermectin is safe even for dogs with the MDR1 mutation. For my Aussie mix, Ive had success using Advantix II. If you have one of those rare dogs who is just going to react to every heartworm medication (fingers and toes crossed thats not the case), then you might want to consider frequent heartworm tests as an alternative to regular heartworm treatment. If your Border Collie does have excessive demodectic mites, giving her an immune system booster might also help, especially considering her age. What do you think about Frontline Gold? The active ingredients of SimpleGuard 3 are the same as Vectra 3D: dinotefuran, pyriproxifen, and permethrin. Once WSU has determined your dogs MDR1 status,board- certified veterinary pharmacologistDr. Katrina Mealey, who discovered the MDR1 genetic mutation in dogs and cats, can work with you and your veterinarian through our online portal to determine the best course of action should your pet need to be treated with a medication known to cause adverse reactions. The more common complaint with Frontline Plus is that its not strong ENOUGH for a lot of people, since it lacks repellent properties. I havent had a Sheltie myself, but my friends who own Shelties have told me that they share many of the same sensitive skin issues with Collies. We may earn a small commission if you make a purchase through an affiliate link in this article. After talking to a variety of Collie people, Frontline seems to be the most trusted of the topical flea/tick products available. Under many circumstances, newer dog flea collars are safe options for flea and tick control (unlike older collars, which were largely ineffective). No one knows yet why some dogs react to isoxazolines like Simparica and others dont, and theres no way to know until its tested on an animal. Is it safe to give an occasional one to him even though hes on Bravecto 1-month? The fleas have to bite for the product to work, and in some places fleas seem to have developed a resistance to it. But of course, do talk to your vet and see what they know. Congratulations on the new kitten. With complaints rolling in, the company made adjustments to the Ivermectin content in their product, and Heartgard is now advertised to be safe at the recommended dosage. But according to Dr. Judy Morgan, Neurologic side effects are a possibility with Heartgard., Also, some veteran Collie breeders and owners have horror stories of even MDR1-clear Collies having adverse reactions to medications containing Ivermectin. What are your thoughts on that? That being said, if a dog was known to be heartworm-negative and the dogs owner would remember to administer a daily dose, I think it could make a good alternative heartworm preventive. they have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. Dinotefuran in particular is a strong pesticide, and all 3 of those ingredients combined are harsh on sensitive skin. In a recent laboratory study, Simparica Trio, containing 24 g/kg moxidectin, 1.2 mg/kg sarolaner and 5 mg/kg pyrantel, and Heartgard Plus and Interceptor Plus (n = 6) were administered in six consecutive monthly oral doses at the labeled dose rates after receiving an inoculation of 50 ZoeLA strain D. immitis L3 on day 30 [].Dogs were necropsied approximately 9 months post-inoculation and . But unless your dogs have had a problem with tapeworms (whose segments are visible to the naked eye in dogs poo), then the regular Interceptor should be fine. It targets not only heartworms, but also hookworms, roundworms, and whipworms. Im trying to find out if this is safe for her. I found this after hearing about the Seresto issues and how they werent accurately reporting data. My Collie is double MDR1 mutant. Also, it might be helpful for you to go to the Quick Nav box near the top of the article and just read or reread the intro and the sections on heartworm meds and oral flea/tick meds if you want a deeper understanding of this topic. She didnt recommend imodium because of the adverse reactions in dogs with mdr1. The warning applies to medications in the isoxazoline class specifically . Other drugs include Immodium and some chemotherapy drugs; there are others. A good spritz-down before you and your girl go into the woods should repel the ticks. Heartgard got a bad rap after too many dogs had negative reactions to the medication. Emily is an avid writer, blogger, and Collie lover who collects and posts stories about Collies from around the world. Giardia can be passed to and cause diarrhea in humans. But remember, dogs can also be sensitive to essential oils just like my friend who is allergic to lavender so natural doesnt automatically mean best for your dog either. To give Sentinel a boost, I recommend using it in conjunction with a weekly topical spray like Natural Chemistry. (I googled veterinary pharmacists near me and found one locally, but Jacksonville is a huge city.) I gave Advantage Multi a caution rating (mostly due to the negative effects that can occur if its ingested) and Advantage II a safe rating. I just quote the ones who are knowledgeable about MDR1. Thanks. The drawback of using them is that they generally dont take care of as large a range of parasites as using two separate medications does. SIMPARICA TRIO is not effective against adult D. immitis. A dog on Heartgard may heaven forbid, but dogs can be gross eat the feces of an animal who was given an Ivermectin-based medication. This study investigated the safety of oral administration of fluralaner at 3 times the highest expected clinical dose to Multi Drug Resistance Protein 1 (MDR1(-/-)) gene defect Collies. Scroll down to read their comments. We are waiting for the results from her test for the MDR1 gene. Last year I used Frontline Plus with no issues. Most vet offices carry some as it often considered safest for dogs with MDR1, and usually they will be willing to sell you one dose as a trial product rather than buying an entire box. If you are able to keep your dogs separated from your cats for 24hrs, the added protection against mosquitoes that K9 Advantix II provides from the possible diseases they carry seems like a greater pro to con ratio. Simparica Trio is generally well tolerated at the recommended dose; adverse reactions (t ransient ataxia and/or muscle fasciculation in dogs with a deficient multidrug -resistance-protein 1 (MDR1 -/-)) are only seen at overdoses. Thank you for the warning. mg) Indications What an awesome article. On the down side, it does not cover any ticks. I opted to supplement Credelio or Frontline with the Natural Chemistry repellent spray, and that seems to work pretty well for us. They were constantly scratching, and the symptoms did not subside until I washed it off. Trish. The back label warns that it may be fatal for cats, and advises cats and dogs should be kept apart for 24 hours following application. Heartgard has been out long enough that there are cheaper knockoffs available. Is this true? I have to tell you that I am no expert, but I would feel the same and be wary of giving Interceptor Plus again. Any of the -mectins are only safe for MDR1-prone breeds at the recommended dosage. A combination of -mectin in topical and oral form could definitely cause negative reactions if any of your foster puppies have MDR1. Either Sentinel or Interceptor are generally considered safe for Collies and can be used to treat demodectic mange. She has shown personality signs of that condition ever since, which are controlled by a dose of a quarter pill of trazadone as needed. I doubt these would be cheaper than fipronil but it's worth checking. Revolution and Stronghold even tested safe over the recommended monthly dosage for dogs with the MDR1 gene, and they hold the distinction of being the only heartworm meds that did not produce any negative drug reactions. For me, every medicine has its side effects, and it really comes down to weighing the risk of side effects against the risks posed by parasites. Though I already mentioned Nexgard as being included in the FDA statement, Im dealing with it separately because it is such a well-known product. Best of luck to you and Sugar! (The Environmental Protection Agency is responsible for approving external flea and tick products.) We have a rescue Aussie mix (with white on all four paws) and one vet put her on Interceptor but the most recent vet said we should use Simparica Trio for her. Ask the Vet, continued Dogs with the MDR1 mutation may not produce enough of this protein, which can lead to a build-up of drugs in their system, causing toxicity. 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Both heart-worm and tick products. ) if your Border Collie does have excessive demodectic mites, her... Bite for the first is simparica safe for mdr1 dogs years following their release. ) stored with diatomaceous earth to keep safe! I have been told that Advocate is safe for MDR1-prone breeds at the dosage. Idea to consult with a history of seizures just like Bravecto and Nexgard it destroys flea and prevention. Will cause neurological toxicity in dogs with the MDR1 mutation for use with Caution in dogs the.